These events occur every couple of hours in certain regions of the map, and one of the biggest reasons to venture into these deadly Helltide regions is to find and unlock rare Mystery Chests (or to use their full name, Tortured Gifts Of Mysteries) filled with oodles of valuable loot. Looking for all the Mystery Chest locations in Diablo 4? Blizzard's latest action RPG is absolutely packed with post-campaign endgame content, and a significant portion of that Diablo 4 content revolves around Helltide events.
